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Potential analytical methods include: High-performance liquid chromatography Mass spectrometry Metal-content analysis Spectroscopic characterization Peptide-content analysis Aggregation assessment Charge-variant analysis Stability-indicating methods No single method fully characterizes sequence identity, copper coordination, purity, complex stability, and biological activity
Papadimitriou M-A, Panoutsopoulou K, Pilala K-M, Scorilas A, Avgeris M
Drop back to the previous dose and attempt escalation again after an additional 2-4 weeks
J.LichtmanA
Ask whether your medical history changes the risk discussion
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