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Seek medical advice if you experience: Persistent or worsening low mood lasting more than two weeks, particularly if accompanied by loss of interest in activities you usually enjoy, feelings of hopelessness, or thoughts of self-harm Severe anxiety or panic attacks that interfere with daily functioning Significant changes in sleep patterns , such as insomnia or excessive sleeping Marked irritability or anger that is out of character or affecting your relationships Symptoms of hypoglycaemia (shakiness, sweating, confusion, rapid heartbeat) occurring frequently, as these require medication adjustment