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Patients with persistent heartburn despite optimal PPI therapy or those with alarm symptoms (difficulty swallowing, weight loss, anemia) should be referred for endoscopic evaluation according to clinical guidelines
High stress levels can slow motility and worsen constipation
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doi: 10.1007/s11306-020-01744-5 Summary Keywords human gastrointestinal microbiome, gut-brain axis, neuroimmunomodulation, enteric nervous system, neurogenic inflammation, neurodegenerative diseases, neuropathology, neuroinflammatory disease Citation Warren A, Nyavor Y, Zarabian N, Mahoney A and Frame LA (2024) The microbiota-gut-brain-immune interface in the pathogenesis of neuroinflammatory diseases: a narrative review of the emerging literature
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