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The largest psychiatric meta-analysis to date 80 randomized controlled trials, over 107,000 patients also found significant improvements in restrained eating and emotional eating with GLP-1 medications compared to placebo ( Pierret et al., JAMA Psychiatry, 2025 )
If you already have gastroparesis or severe chronic GI disease, this can worsen symptoms
Subject demographics (for example: age, sex, self-identified race), lab values (for example: HbA1c, BMI, liver enzymes), and some medication information (GLP-1 M, other drugs used to treat T2D, and NSAIDs) and presence or absence of diabetes-associated complications (for example: chronic kidney disease, cardiovascular disease) were extracted as prediction features
The prescribing information notes that gastrointestinal adverse effects are the most common reasons for treatment discontinuation
IGF-1 activates the PI3K-Akt-mTOR pathway in muscle satellite cells, driving their proliferation and differentiation into new myofibers
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