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In general, intensification of treatment beyond two medications follows the same general principles as the addition of a second medication, with the assumption that the efficacy of third and fourth medications will be generally less than expected
Additionally, it downregulates the expression of pro-inflammatory cytokines IL-1 and TNF- in the hippocampus of mice while up-regulating the expression of anti-infective cytokines IL-10 and BDNF
It may take time for the injury to become apparent
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This is because medications gain approval for different uses
Do they require prior authorization
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