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These guidelines, however, do not give a preference regarding which of the second-line agentswhich also include sulfonylureas (SU), dipeptidyl peptidase-4 inhibitors (DPP-IV), sodium-glucose cotransporter 2 inhibitors (SGLT-2i), insulin, thiazolidinediones (TZD) and acarboseshould be added to optimised metformin [13, 14]

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Conclusion GLP-1 agonists are pivotal in managing type 2 diabetes and supporting weight loss by mimicking natural hormonal actions that regulate insulin, glucose, and appetite

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