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That is what we have started this week with tirzepatide. Trial protocols call for half of the 1,000 participants to receive a placebo, inert doses that have no effect, rather than the active drug, creating a control group that is critical to obtaining scientifically valid results
Patients who have undergone gastric sleeve surgery should maintain regular long-term follow-up with their bariatric team, as recommended by NICE and BOMSS guidelines
References NHS England: Implementation of NICE TA1026 for Tirzepatide (Mounjaro) NHS England: Medicines for obesity Focus On: Tirzepatide for Weight Management in General Practice (2025) Senedd Research: What next for weight-loss medication in Wales
Some can improve blood sugar with nutrition changes, increased activity, sleep optimization, and targeted weight reduction alone
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