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These findings suggest that fixed BMI eligibility criteria are associated with substantially lower estimated trial-eligible proportions among Asian populations, supporting further evaluation of ethnicity-sensitive BMI thresholds in future GLP-1 RA trial design

[Ref] Renal Common (1% to 10%): Kidney failure (chronic hemodialysis patients) [Ref] Endocrine Common (1% to 10%): Parathyroid disorder [Ref] Respiratory Very common (10% or more): Pharyngitis (27%), cough increase (18%), dyspnea (11%), rhinitis (11%) Common (1% to 10%): Bronchitis, sinusitis [Ref] Dermatologic Common (1% to 10%): Pruritus, rash [Ref] Ocular Common (1% to 10%): Amblyopia, eye disorder [Ref] Genitourinary Common (1% to 10%): Urinary tract infection [Ref] Cardiovascular Very common (10% or more): Hypertension (21%), hypotension (19%) Common (1% to 10%): Atrial fibrillation, arrhythmia, cardiovascular disorder, electrocardiogram abnormal, palpitations, tachycardia, vascular disorder [Ref] Hypersensitivity Common (1% to 10%): Allergic reaction [Ref] Psychiatric Common (1% to 10%): Depression, anxiety, drug dependence, insomnia [Ref] Immunologic Very common (10% or more): Infection (24%) [Ref] References 1

This is especially important if you're taking medications or have pre-existing health conditions

While we included extensive data on comorbidities and concomitant medications, information on reasons for treatment discontinuation, such as gastrointestinal adverse effects, was not available

Also, some of the links between Akkermansia supplementation have not been quantified by numbers