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The IDH3 isoform is involved in the TCA cycle where it oxidatively decarboxylates isocitrate to 2-oxoglutarate (-ketoglutarate)
DESCRIPTION OF EXEMPLARY EMBODIMENTS [00024] In this specification and in the claims that follow, reference will be made to a number of terms that shall be defined to have the following meanings: [00025] Throughout this specification, unless the context requires otherwise, the word "comprise," or variations such as "comprises" or "comprising," will be understood to imply the inclusion of a stated integer or step or group of integers or steps but not the exclusion of any other integer or step or group of integers or steps
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