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In addition, cross-breeding ALS-transgenic mice with ARE-human placental alkaline phosphatase (hPAP) reporter mice allowed to reveal that Nrf2 activity was more intense in skeletal muscle than in the spinal cord, and evident since before motor symptom onset [264]

Most of the biologically active T 3 in the circulation and inside cells is generated by the removal of one iodine atom from T 4 in a reaction catalyzed by selenium-dependent iodothyronine deiodinase enzymes

Starting from the square-cube law equations [1] [2] , an equation for the change in brain volume proportional to the change in brain surface area [6] was derived

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Stress also plays a significant role: cortisol spikes can trigger or worsen outbreaks in susceptible individuals