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Oral GLP-1 medications reduce some barriers associated with injectable administration particularly convenience and needle aversion and may broaden uptake among patients who previously declined injectable therapy
Pulmonary administration enables high local drug concentration, rapid action, and bypasses the first-pass effect, making enzyme-responsive micro-/nanoparticles an attractive strategy for site-specific treatment in the inflamed lung 78
These symptoms should improve with continued use, not worsen indefinitely
In a smaller cohort of patients with more severe CD phenotypes, including 17% with perianal involvement and 24% with penetrating or fistulizing disease, numerical reductions across outcomes were observed in the GLP-1RA group, but these differences did not reach statistical significance (104)
A 1mg dose equals 0.05mL or 5 units
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