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Next, ice-cold Milli Q water (1.25 ml) and chloroform (1.25 ml) were added to the sonicated mixture, followed by rapid vortexing
Similarly, effects on children and adolescents are unknown, and use in these populations cannot be recommended
However, owing to variations in the composition of the gut microbiota, only a limited percentage of individuals can effectively synthesize UA, with UA production fluctuating with age and environmental influences
DPP-4is were selected as the active comparator because they are incretin-based therapies with similar clinical indications and treatment timing, thereby reducing confounding by indication ( Eligibility criteria and cohort assembly The study population was identified from individuals with healthcare encounters recorded between January 1, 2018, and December 31, 2022
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