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Patients with established cardiovascular disease should receive a pharmacological treatment intensification with an agent that has demonstrated benefit in cardiovascular safety studies: In patients with pre-existing atherosclerotic cardiovascular disease (ASCVD), a GLP-1 receptor agonist, or SGLT-2 inhibitor with characterized cardiovascular safety should be used

ER stress and oxidative stress are especially well-documented contributors to this effect (Kerry et al., 2005

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Low-density lipoproteins cause atherosclerotic cardiovascular disease

Glutathione in its reduced form scavenges free radicals