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Metformin attenuates hypothalamic inflammation via downregulation of RIPK1-independent microglial necroptosis in diet-induced obese mice
Week 1: Early Pharmacodynamic Changes What the trials documented: The Phase 1b combination study measured reduced food intake and slowed gastric emptying among the earliest pharmacodynamic signals after dosing began, while the dose was still at the lowest titration step (Enebo et al., 2021)
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