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recently showed that direct GPx4 overexpression in the cellular models (A549, H460 and H1299 and H23) of non-small cell lung carcinoma (NSCLC) prevented the radiation-induced lipid peroxidation and, in turn, contributed to radioresistance by blocking the ferroptosis mode of cell death [56]

Glutathione deficiency states include, but are not limited to, HIV/AIDS, chemical and infectious hepatitis, myalgic encephalomyelitis chronic fatigue syndrome, prostate and other cancers, cataracts, Alzheimer's disease, Parkinson's disease, chronic obstructive pulmonary disease, asthma, radiation poisoning, malnutritive states, arduous physical stress, and aging, and has been associated with suboptimal immune response

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Delivering large molecules through skin is inherently difficult