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A key finding was its ability to reduce phosphorylation of myosin light chain-2 through inhibition of the ROCK pathway, a central regulator of perijunctional actomyosin contraction and barrier leakiness
The increased cAMP levels in cardiac cells activate exchange protein directly activated by cAMP (EPAC) and protein kinase A (PKA), which regulate a multitude of downstream effectors involved in cardiac contractility, relaxation, and hypertrophy [14]
In addition, mitochondria were slightly swollen, and the mesenchymal endoplasmic reticulum was slightly expanded
Bliddal H, Bays H, Czernichow S, et al
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