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Guidelines suggest monitoring monthly for the first three months and continuing a specific agent when patients lose at least 5% of their initial body weight in that window, absent safety or tolerability concerns
In addition, HFD also promotes apoptotic processes at the hypothalamic level 62 , and weight-lowering therapies, as exercise, contribute to mitigate apoptosis in hypothalamic neurons 60
For expert advice, I reached out to Robyn Siperstein, MD, FAAD, a dermatologist in Boca Raton and Boynton Beach, Florida
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