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(00:24:31) Brandon Owen: So, um, long, long answer to basically say that it's also important
[5] Sleep Architecture Modulation : Animal and limited human studies indicate that DSIP may increase the duration of slow-wave sleep without significantly affecting rapid eye movement (REM) sleep, which could support improved restorative sleep and cognitive function
Claudin-15 forms a water channel through the tight junction with distinct function compared to claudin-2
doi: 10.1634/theoncologist.2010-0366
Besides, it is possible to add mucoadhesive agents to the formulation, which can improve biodistribution by increasing the retention time in the brain and the brain/blood ratio [111]
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