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(28) The study included 1,222,436 patients with type 2 diabetes who were newly prescribed SGLT-2 inhibitors, GLP-1 agonists, DPP4-Is, or older antidiabetic agents (metformin, sulfonylureas, alpha glucosidase inhibitors, thiazolidinediones), with patients categorized based on their first recorded prescription
The DiMarchi/Tschp paper provides a mechanistic explanation for why a triple agonist outperforms a single agonist that goes deeper than "more receptors = more effect." Glucagon and GIP appear to do real, independent work on adipocyte and hepatic metabolism
doi: 10.1111/exd.12081 187 HoganAETobinAMAhernTCorriganMAGaoatsweGJacksonRet al
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