The two programs share a molecule but differ in population, endpoints, and duration
This is very exciting because breast cancer is one of the obesity associated cancers and bariatric surgery, while effective to reduce breast cancer risk, is not scalable at a population level. Elizabeth McDonald, MD, PhD Additionally, estrogen blockers, while effective and necessary when recommended by a physician, have unfortunate side effects that reduce compliance and also limit their use to women at high risk of breast cancer, she added
Conversely, in lung and breast cancer, elevated CHAC2 correlates with advanced tumor stage and grade, indicating a worse prognosis (Liu et al., 2017
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The ability of metformin to increase GLP-1 levels independently of effects on DPP-4 suggests there could be a direct benefit in terms of incretin action by combining metformin with DPP-4 inhibitors