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Clinical trials have shown its effectiveness when combined with lifestyle changes
A well-designed meal plan that emphasizes protein and micronutrients helps prevent muscle loss and deficiency-related side effects
Protein-rich foods can stimulate GLP-1 secretion
The driving mechanism is likely weight loss, given that obesity is the primary modifiable risk factor for OSA
Instruct patients if symptoms of allergic reactions (including skin rash, hives and swelling of the face, lips, tongue and throat that may cause difficulty in breathing or swallowing) occur, patients should discontinue alogliptin and pioglitazone tablets and seek medical advice promptly [see Warnings and Precautions (5.3)]
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