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The researchers also conducted RNA-sequencing, which apparently pointed to reduced activity of pathways involved in ECMreceptor interaction and focal adhesion, alongside lower levels of key ECM proteins such as fibronectin, tenascin C, laminin, thrombospondin-2, and Hmmr
doi: 10.3389/fnut.2023.1120168 91
The 1.75 mg bremelanotide dose was chosen based on earlier dose-finding studies, demonstrating optimal efficacy and safety
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