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Depending on the metal type, Hg, Cd, As, Ag, and Fe have been reported as strong inducers of PCs while Pb and Zn are weak inducers and Cu and Ni are moderate inducers (Zenk, Hordeum vulgare aerial parts than in H

Additionally, hepatokines play a role in IR and lipid metabolism in conditions like obesity, type 2 diabetes mellitus (T2DM), and other metabolic disorders, suggesting their potential as novel regulators of energy metabolism [8, 9]

In addition to exacerbating gliosis and inflammation, BBB disruption also leads to oxidative damage such as in ischemia-reperfusion injury where SOD1 deficiency causes exacerbated neuronal damage and infarct volume (Gasche et al., 2001)

Injections of B12 are useful in such cases

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