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While it's now being introduced in some NHS specialist weight management services, it's also available privately for weight loss through registered online pharmacies and private clinics, including Phlo Clinic
According to a retrospective review comparing amphetamine-derived phentermine with phentermine-topiramate, phentermine and phentermine-topiramate in addition to diet and exercise in post-RYGB and LAGB patients induced weight loss of 6.35 kg (12.8% excess weight loss) and 3.81 kg (12.9% EWL) within 90 days, respectively [14]
This means you'll naturally eat less, which shouldn't impair methotrexate pharmacokinetics but may affect how you feel while adjusting to both medications simultaneously
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