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Those with conditions like the below may find that these medications worsen symptoms or become difficult to tolerate: Gastroparesis (delayed stomach emptying) GERD or acid reflux IBS or chronic constipation 3

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Most side effects begin: 13 days after the first dose After a new dose escalation When Zepbound is combined with other prescription medications If youre using Zepbound for obstructive sleep apnea , be aware that symptoms like nausea and appetite changes may begin even sooner

A 2025 retrospective analysis published in Ophthalmology Retina evaluated the incidence of DME among patients with type 2 diabetes who took various classes of medications