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In addition, some studies have shown that GLP1R agonists can improve mortality, increased left ventricular ejection fraction, and attenuate the level of brain natriuretic peptide in the patients with type 2 diabetes and HF 13,14,15

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The broader receptor activity of tirzepatide may contribute to slightly higher rates of early gastrointestinal intolerance, although discontinuation rates remain comparable 7

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