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After excluding occasionality, we hypothesized that this may be due to the excitability of SNS by GLP-1RA, especially exenatide, in line with the findings of multiple preclinical studies that showed that Exendin may acutely activate SNS, and this effect independent of insulinotropic and hypothalamus-pituitary-adrenal axis activation can be blocked by GLP-1 antagonist
Overall, the efficacy of semaglutide in weight reduction was demonstrated in patients both with concomitant T2Dspecifically in STEP 2 [39], which included only patients with T2D, as well as in STEP 6, 7, and 10, which included both patients with and without T2D [41,42,43]and without diabetes (STEP 1, 3, 4, 5, 8, and 9) [13, 38, 40, 44,45,46]
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Poor fat distribution often translates to increased cholesterol and hypertension
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