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Unfortunately, due to the lack of high quality clinical trials with berberine to date, its difficult to defend its primary use in weight loss
Angeli V , Llodra J , Rong JX , et al
This is more critical with tirzepatide due to its stronger glucose-lowering effect
"In patients with diabetes, GLP-1 RA initiation similarly resulted in a lower risk of requiring extra glucose-lowering therapy, but there was no difference in nonadherence rates when compared to metformin initiation," the researchers wrote
2,948 had high-risk CKD
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