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The answer is yesthey work synergistically for better results

Following sublingual administration, Drug A is 100 % bioavailable while following rectal administration, Drug A bioavailability is between 40 and 100 %, depending how far up the rectum the drug product is inserted Measurement of Bioavailability For intravenous injection, the whole of drug dose is delivered directly into the systemic circulation, thus it will always have 100 % bioavailability (F = 1) and the maximal plasma concentration (C max ) is reached instantaneously (T max = 0 min)

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Diseases and Conditions 2011a

Following 8 h of magnetic stirring at 25 C, mPEG5000-OH (1.35 g, 0.27 mmol) was incorporated into the reaction system