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As versatile therapeutic agents, GLP-1RAs demonstrated their benefits across a range of pain syndromes, including inflammatory nociception, visceral hypersensitivity, neuropathic pain, diabetic peripheral neuropathy (DPN), cancer pain and headaches (Fig

Mitochondria are both a source and a target of ROS [85]

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Another TCM-based formulation, Shenshuaining (SSN)composed of extracts from Astragalus membranaceus (Huangqi), Salvia miltiorrhiza (Danshen), and Rehmannia glutinosa (Dihuang)has demonstrated significant therapeutic efficacy in patients with DKD