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Needle-free delivery could be a game changer for adherence in chronic care
Vrang, N
doi: 10.1016/j.cmet.2017.03.008 71 PetersenNReimannFBartfeldSFarinHFRingnaldaFCVriesRGet al
48 As an add-on to insulin with or without metformin (PIONEER 8), oral semaglutide (at doses of 3, 7 and 14 mg) was shown to be associated with superior HbA1c and body weight reductions versus placebo as early as at week 26 and achieved further reduction in insulin need (except dose 3 mg) at week 52, without significantly increasing the rate of hypoglycemia
In addition, mice with T2DM treated with dapagliflozin for eight weeks demonstrated significantly less arterial stiffness, improvements in endothelial and vascular smooth muscle dysfunctions, and reductions in circulating markers of inflammation compared with non-treated diabetic mice (55)
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