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Peptides (2018) 100:4247
Since natural GLP-1 is rapidly deactivated by an enzyme in our blood, by the time GLP-1 is secreted by our gut, makes it through our liver, heart, and lungs, then out into our arteries, only to later reach the veins where the lab tech is pulling out blood, the levels we see are lower than the arterial levels that GLP-1 receptors are exposed to throughout our body, though only by a relatively small amount
5, pp2784-2790 [online] Available at: Miranda, J., Lasa, A., Bustamante, M.A., Churruca, I
That is why semaglutide is much less likely to cause dangerous low blood sugar than direct insulin
E., Cooper, M
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