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Together with CDK inhibitors (CKIs), RETINOBLASTOMA-RELATED (RBR) proteins, and E2F/DP complexes, CYC-CDK complexes control the unidirectional progression through the different phases in the cell cycle

However, they increase risks of weight gain, osteoporosis, glucose intolerance, and susceptibility to infections with chronic use

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Pre-existing conditions such as liver disease, kidney problems, or known allergies can increase the risk of adverse reactions