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A phenomenon called metabolic adaptation occurs after weight loss, in which your metabolic rate (the number of calories you burn at rest) decreases to a greater extent than expected based on your new weight

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Additionally, the deletion of Meis1, 101 a key transcriptional regulator of the cell cycle and its cofactor Hoxb13, 102 has been found to extend the proliferation window of postnatal cardiomyocytes and reactivate mitosis in adult hearts

, Berlin, Heidelberg: Springer Berlin Heidelberg, pp