Wadden, T
Despite this, a substantial body of pre-clinical and limited clinical research has mapped DSIPs pharmacological effects across multiple systems, identifying several probable mechanistic axes including NMDA receptor modulation, adrenergic system regulation, MAPK/ERK cascade interaction, and mitochondrial respiration effects while acknowledging that the existence of an undiscovered DSIP-like endogenous peptide(s) may account for part of the DSIP-like immunoreactivity observed in tissue distribution studies
10.1038/nrrheum.2013.14 Nat
This report examines the current state of that gap in detail, its regulatory context, its variation across race, ethnicity, sex, age, and disease area, and what the evidence suggests for sponsors, sites, and life-science organizations navigating compliance in 2026
Do either of these have long-term outcome data