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Auspiciously, we found that PKM2 mediates DRD2-induced GSH production and is selectively expressed in astrocytes, indicating that PKM2 dimerization is an ideal approach to restore GSH synthesis and prevent side effects induced by effects on neuron functions

Raychaudhuri, S

Verhoef P, Kok FJ, Kluijtmans LAJ, Blom HJ, Refsum H, Ueland PM, and Kruyssen DACM (1997a)

Methods Animals We used 6-week-old male C57BL/6J mice (obtained from the Experimental Animal Center of Tongji Medical College, Huazhong University of Science and Technology) and 6-week-old male Nrf2 knockout mice (B6.129 1-Nfe2l2 tm1Ywk /J, purchased from Jackson Laboratory, Bar Harbor, ME) for the experiments

They don't just neutralize harmful free radicals