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Critical roles in maintaining redox are exerted by antioxidant systems, including the thioredoxin/peroxiredoxin systems and the nuclear erythroid related transcription factor 2 (Nrf2), which regulates the expression of detoxification proteins such as Kelch-like ECH-associated protein 1 (Keap1) [181]

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As research continues, FOXO4-DRI remains a compelling compound for ongoing laboratory investigation into senescence biology and transcriptional control mechanisms

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Chemokine and Chemokine Receptor Expression in Paired Peripheral Blood Mononuclear Cells and Synovial Tissue of Patients With Rheumatoid Arthritis, Osteoarthritis, and Reactive Arthritis