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Phase 2 trial data (Jastreboff et al., NEJM 2023) demonstrated average weight reductions of approximately 1724% over 48 weeks notably higher than currently approved GLP-1 receptor agonists such as semaglutide, though direct comparisons are limited by differences in trial populations and designs

Neutral or near-isoelectric peptides, those carrying little or no net charge at a given pH, are far more prone to aggregation and precipitation during reconstitution

Vaccaro et al

This trend is also seen in Figure 2G , which presents a scatter plot of the study group subtraction from control group

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