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Older adults, vegetarians, vegans, and people with digestive problems that can impede nutrient absorption are at a higher risk of vitamin B12 deficiency and need to supplement
doi:10.1152/japplphysiol.00945.2010 Sikiric P, Blagaic AB, Strbe S, et al
NNMT acts as a primary metabolic gatekeeper, predominantly active in fat tissue and liver cells, where it methylates nicotinamide (NAM) using S-adenosyl-L-methionine (SAM) as a methyl donor
In addition to blocking more fat formation, this dual action helps decrease stored fat
However oral B12 was much slower to recover deficiencies than injections and do not last in the body as long as injections.
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