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In naturally aged mice, FOXO4-DRI improved the testicular microenvironment and alleviated age-related testosterone secretion insufficiency with decreased p53, p21, and p16 protein levels in treated testes compared to aged controls
The structurally simplified Ang IV peptidemimetic 16 was almost as active as Ang IV as an IRAP inhibitor while 17 was five-fold and 18 and the open chain 19 were 20-fold less active (Figure 5)
Sardinia MF, Hanesworth JM, Krishnan F, Harding JW
Alpha-MSH has been studied for anti-inflammatory effects across multiple inflammatory models, but the full parent molecule can also interact with melanocortin receptors involved in pigmentation and other biological effects
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