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There are even fewer studies supporting the effect of other types of DPP-4 in NAFLD: in a double-blind RCT involving 44 patients with well-controlled T2DM vildagliptin was proven to reduce liver trygliceride content assessed by MRI along with achieving a significant improvement in serum transaminase and fasting plasma glucose after a 6-month course
Interestingly, however, in the case of hip fractures, we found a statistically significant effect of GLP-1 RAs compared to DPP-4i with risk reductions of as much as 30-35%
Vittone, J., et al
per 100 ml
Continued use maintains results, but consistency is essential
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