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However, it is important to note that humans have fewer C-cells and GLP-1 receptors in the thyroid gland compared to rodents, and no C-cell changes have been observed in clinical trials involving patients treated with GLP-1 RAs [26]
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To address this need, we conducted a systematic review and meta-analysis to evaluate and compare the efficacy of GLP-1 RAs in promoting weight loss and modulating body composition in individuals with overweight or obesity with or without T2DM
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