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Fourth, the median follow-up duration in several trials was less than 5 years, which may not be sufficient to detect late-onset malignancies, particularly for solid tumors
Predicting value of pain and analgesia: nucleus accumbens response to noxious stimuli changes in the presence of chronic pain
Some healthcare professionals may recommend a gradual reduction in dose or frequency, not because of withdrawal concerns, but to allow for careful monitoring of metabolic changes and adjustment of other medications
& Taylor, E
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