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However, the process of making ATP also produces reactive oxygen species (ROS), such as hydrogen peroxide, which can damage the cell at higher levels
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A high uptake of glucose in tumor cells not only serves for energy production but also for protection from endogenous and exogenous reactive oxygen species because NADPH, a by-product of the oxidative pentose phosphate pathway, is used to regenerate glutathione, an important cellular antioxidant
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