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5-8 weeks : Your healthcare provider will increase the dosage to 2 mg once weekly
In normal physiology, the majority of circulating IGF-1 is bound to IGFBP-3, forming a large ternary complex with the acid-labile subunit that prevents rapid clearance and buffers free IGF-1 within a tightly controlled range
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Callis A
Kelvas says people tend to have fewer side effects with the once-daily dosing than the weekly dosingand that might mean you notice an increase in gastrointestinal (GI) side effects when switching from Saxenda to Wegovy
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