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Applying REWIND cardiovascular disease criteria to SUSTAIN 6 and PIONEER 6

These drugs can make the inner ear more permeable, letting harmful substances reach the cochlea

These might be indications that youre losing too much muscle, and you may need to make adjustments to optimize your outcomes

New England Journal of Medicine 320, 479484, 10.1056/Nejm198902233200802 (1989)

Tirzepatide combines GLP-1 activity with GIP activity, another hormone involved in metabolic regulation, which may help explain why its weight-loss results have outpaced earlier medications in clinical trials