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184 The most prevalent DNA lesions include single-strand breaks (SSBs) and double-strand breaks (DSBs), which are sensed by key damage sensors such as ataxia telangiectasia mutated (ATM), ATM and Rad3-related (ATR), and poly (ADP-ribose) polymerase 1 (PARP1)

M., Falkenberg, M

Methodology This review is based on a thorough literature analysis from PubMed, ScienceDirect, and Google Scholar from 2000 to 2025, with some important older articles included based on their significance

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Kolijn, D., et al., Empagliflozin improves endothelial and cardiomyocyte function in human heart failure with preserved ejection fraction via reduced pro-inflammatory-oxidative pathways and protein kinase G oxidation