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How the MHRA Assesses a Product MHRA guidance explains that a product may be a medicine when it is presented as treating or preventing disease

Age-related decline in NAD+ can cause low energy and poor cognition

This matters because it shows how researchers expand the endpoint set depending on population and protocol: weight endpoints remain central, while glycaemic endpoints are included when the population and study design require them

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While preclinical studies, primarily in animal models 17,18 , suggest a potential beneficial effect of GLP-1 RAs on mood and behavior, the clinical evidence in humans remains unclear 19,20