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A significant upregulation of mucosal IL23p19 , IL23R and IL17A expression was detected in patients who did not respond to anti-TNF- therapy, in association with elevated number of mucosal T cells which expressed both TNFR2 and IL-23R and demonstrated high expression of inflammatory genes and resistance to apoptosis [172]

Some patients report localized inflammation at injection sites, while others experience systemic reactions such as rashes or flu-like symptoms

Storage and Labeling Reconstituted peptides should be stored at 2-8C in standard refrigeration

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However, the effectiveness of these injections can vary from person to person