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It was shown that monocytes from G6PD-deficient AA subjects show a significantly higher peroxide content and increased expression of CD11b compared with those from nondeficient AA subjects
Metabolism 97 (10), 37993806
For instance, the rs2476601 coding variant of PTPN22 (R620W) alters T cell activation and proliferation
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This is the mechanistic basis for the compound's metabolic effects
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